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Items: 8

1.

β-catenin safeguards the ground state of pluripotency by strengthening the robustness of the transcriptional apparatus [ATAC-seq]

(Submitter supplied) Mouse embryonic stem cells (ESCs) cultured with inhibitors of MEK and GSK3 (2iL) more closely resemble the pre-implantation embryo inner cell mass than cultures in serum/LIF (SL). Unveiling the differences between both systems is important for understanding development and could also assist in isolating an ESC equivalent for other mammalian species. In SL, pluripotency and cell cycle gene transcription is a multistep process requiring release of promoter-proximal paused RNA polymerase II (Pol2) by the histone acetylation reader BRD4 and the Pol2 kinase CDK9. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
6 Samples
Download data: BW
Series
Accession:
GSE123690
ID:
200123690
2.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
3.

mESC_ATAC-seq_2iL_rep3

Organism:
Mus musculus
Source name:
mouse embryonic stem cells
Platform:
GPL19057
Series:
GSE123690 GSE123692
Download data: BW
Sample
Accession:
GSM3509513
ID:
303509513
4.

mESC_ATAC-seq_2iL_rep2

Organism:
Mus musculus
Source name:
mouse embryonic stem cells
Platform:
GPL19057
Series:
GSE123690 GSE123692
Download data: BW
Sample
Accession:
GSM3509512
ID:
303509512
5.

mESC_ATAC-seq_2iL_rep1

Organism:
Mus musculus
Source name:
mouse embryonic stem cells
Platform:
GPL19057
Series:
GSE123690 GSE123692
Download data: BW
Sample
Accession:
GSM3509511
ID:
303509511
6.

mESC_ATAC-seq_SL_rep3

Organism:
Mus musculus
Source name:
mouse embryonic stem cells
Platform:
GPL19057
Series:
GSE123690 GSE123692
Download data: BW
Sample
Accession:
GSM3509510
ID:
303509510
7.

mESC_ATAC-seq_SL_rep2

Organism:
Mus musculus
Source name:
mouse embryonic stem cells
Platform:
GPL19057
Series:
GSE123690 GSE123692
Download data: BW
Sample
Accession:
GSM3509509
ID:
303509509
8.

mESC_ATAC-seq_SL_rep1

Organism:
Mus musculus
Source name:
mouse embryonic stem cells
Platform:
GPL19057
Series:
GSE123690 GSE123692
Download data: BW
Sample
Accession:
GSM3509508
ID:
303509508
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Supplemental Content

db=gds|term=GSE123690[Accession]|query=1|qty=2|blobid=MCID_6675044fccfbad768f943ea6|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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