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Items: 6

1.

Copper regulation of HIF-1 transcriptional activities

(Submitter supplied) HIF-1 regulated VEGF expression were upregulated in reponse to ischemic injury. However, the VEGF mRNA level were increased in the early stage but decreased in the late stage of myocardial infarction. We found that activities of HIF-1 binding to the HRE sites were possiblely responsible for the differential expression of VEGF. The HIF-1 binding activities were regulated by copper. After ischemic injury, copper concentrations were decreased in the infarct myocardium in the late stage of myocardial infarction, which might reduce VEGF expression through insufficient HIF-1 binding to HRE sites.
Organism:
Macaca mulatta
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24522
4 Samples
Download data: BED
Series
Accession:
GSE125755
ID:
200125755
2.

HiSeq X Ten (Macaca mulatta)

Organism:
Macaca mulatta
20 Series
652 Samples
Download data
Platform
Accession:
GPL24522
ID:
100024522
3.

InPut 4w

Organism:
Macaca mulatta
Source name:
myocardial infarction_4 wks
Platform:
GPL24522
Series:
GSE125755
Download data
Sample
Accession:
GSM3581503
ID:
303581503
4.

InPut 6h

Organism:
Macaca mulatta
Source name:
myocardial infarction_6hrs
Platform:
GPL24522
Series:
GSE125755
Download data
Sample
Accession:
GSM3581502
ID:
303581502
5.

MI 4 w

Organism:
Macaca mulatta
Source name:
myocardial infarction_4 wks
Platform:
GPL24522
Series:
GSE125755
Download data: BED
Sample
Accession:
GSM3581501
ID:
303581501
6.

MI 6 h

Organism:
Macaca mulatta
Source name:
myocardial infarction_6hrs
Platform:
GPL24522
Series:
GSE125755
Download data: BED
Sample
Accession:
GSM3581500
ID:
303581500
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Supplemental Content

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