GSE136894[Accession] - GEO DataSets - NCBI

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Items: 14

Select item 2001368941.

β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7

(Submitter supplied) Lysosomal dysfunction is considered pathogenic in Alzheimer Disease (AD). Loss of Presenilin-1(PSEN1) function causing early onset AD impedes acidification via defective vATPase V0a1 subunit delivery to lysosomes. We report that isoproterenol and related β2-adrenergic agonists re-acidify lysosomes in PSEN1 KO cells and fibroblasts from PSEN1 familial AD(FAD) patients, restores lysosomal calcium homeostasis and proteolysis, and reverses impaired autophagy flux. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE136894

ID:: 200136894

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000170212.

Illumina HiSeq 2500 (Mus musculus)

Organism:: Mus musculus

11144 Series
299789 Samples

Platform

Accession:: GPL17021

ID:: 100017021

Select item 3040613063.

WT, ISO treated, replicate 3

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061306

ID:: 304061306

SRA Run Selector

Select item 3040613054.

WT, ISO treated, replicate 2

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061305

ID:: 304061305

SRA Run Selector

Select item 3040613045.

WT, ISO treated, replicate 1

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061304

ID:: 304061304

SRA Run Selector

Select item 3040613036.

WT, replicate 3

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061303

ID:: 304061303

SRA Run Selector

Select item 3040613027.

WT, replicate 2

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061302

ID:: 304061302

SRA Run Selector

Select item 3040613018.

WT, replicate 1

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061301

ID:: 304061301

SRA Run Selector

Select item 3040613009.

PSEN1 KO, ISO treated, replicate 3

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061300

ID:: 304061300

SRA Run Selector

Select item 30406129910.

PSEN1 KO, ISO treated, replicate 2

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061299

ID:: 304061299

SRA Run Selector

Select item 30406129811.

PSEN1 KO, ISO treated, replicate 1

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061298

ID:: 304061298

SRA Run Selector

Select item 30406129712.

PSEN1 KO, replicate 3

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061297

ID:: 304061297

SRA Run Selector

Select item 30406129613.

PSEN1 KO, replicate 2

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061296

ID:: 304061296

SRA Run Selector

Select item 30406129514.

PSEN1 KO, replicate 1

Organism:: Mus musculus

Source name:: Blastocysts

Platform:: GPL17021
Series:: GSE136894

Sample

Accession:: GSM4061295

ID:: 304061295

SRA Run Selector

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