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Items: 8

1.

Sustained fetal hematopoiesis causes juvenile death from leukemia: evidence from a dual-age-specific mouse model

(Submitter supplied) It is not clear whether disrupted age-specific hematopoiesis contributes to the complex manifestations in leukemia patients who carry identical mutations, particularly in pediatric and adult patients with similar clinical characteristics. By studying a dual-age-specific mouse model, we demonstrate: 1) loss of Pten during the fetal-to-adult hematopoiesis switch (HSC switch) causes sustained fetal hematopoiesis, resulting in death in juvenile leukemia; 2) myeloid-biased hematopoiesis in juvenile mice is associated with the sustained fetal properties of hematopoietic stem cells (HSCs); 3) the age specificity of juvenile myelomonocytic leukemia (JMML) depends on the dosage of Pten and Nf1; 4) single-allelic Pten deletion during the HSC switch causes constitutive activation of mitogen-activated protein kinase (MAPK) in juvenile mice with Nf1 loss of heterozygosity (LOH); and 5) Nf1 LOH causes monocytosis in juvenile mice with Pten haploinsufficiency but does not cause lethality until adulthood. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
6 Samples
Download data: TSV
Series
Accession:
GSE137152
ID:
200137152
2.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
3.

WT rep3 [N393-0M]

Organism:
Mus musculus
Source name:
WT
Platform:
GPL21493
Series:
GSE137152
Download data: TSV
Sample
Accession:
GSM4072081
ID:
304072081
4.

WT rep2 [N412-0M]

Organism:
Mus musculus
Source name:
WT
Platform:
GPL21493
Series:
GSE137152
Download data: TSV
Sample
Accession:
GSM4072080
ID:
304072080
5.

WT rep1 [N411-4M]

Organism:
Mus musculus
Source name:
WT
Platform:
GPL21493
Series:
GSE137152
Download data: TSV
Sample
Accession:
GSM4072079
ID:
304072079
6.

JMML rep3 [N393-2M]

Organism:
Mus musculus
Source name:
JMML
Platform:
GPL21493
Series:
GSE137152
Download data: TSV
Sample
Accession:
GSM4072078
ID:
304072078
7.

JMML rep2 [N409-0F]

Organism:
Mus musculus
Source name:
JMML
Platform:
GPL21493
Series:
GSE137152
Download data: TSV
Sample
Accession:
GSM4072077
ID:
304072077
8.

JMML rep1 [N348-0F]

Organism:
Mus musculus
Source name:
JMML
Platform:
GPL21493
Series:
GSE137152
Download data: TSV
Sample
Accession:
GSM4072076
ID:
304072076
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Supplemental Content

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