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Items: 8

1.

Interleukin-1α mediates innate and acquired resistance to immunotherapy in melanoma

(Submitter supplied) In a syngeneic mouse model of melanoma, we found that tumor size was inversely correlated with response to immunotherapy. Large tumors had higher levels of IL-1α, Th2 cytokines, granulocytic myeloid-derived suppressor cells (GMDSCs), and regulatory T cells but lower levels of IL-12, Th1 cytokines, and activated CD4+ and CD8+ T cells. Blocking IL-1 signaling decreased GMDSCs and their associated PD-L1 expression in the tumor microenvironment, and enhanced tumor-specific immunity.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE164357
ID:
200164357
2.

Illumina MouseWG-6 v2.0 expression beadchip

(Submitter supplied) The MouseWG-6 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...
Organism:
Mus musculus
31 DataSets
1216 Series
8 Related Platforms
17093 Samples
Download data: BGX, TXT
Platform
Accession:
GPL6887
ID:
100006887
3.

S3 Small tumor

Organism:
Mus musculus
Source name:
B16 melanoma
Platform:
GPL6887
Series:
GSE164357
Download data
Sample
Accession:
GSM5008104
ID:
305008104
4.

S2 Small tumor

Organism:
Mus musculus
Source name:
B16 melanoma
Platform:
GPL6887
Series:
GSE164357
Download data
Sample
Accession:
GSM5008103
ID:
305008103
5.

S1 Small tumor

Organism:
Mus musculus
Source name:
B16 melanoma
Platform:
GPL6887
Series:
GSE164357
Download data
Sample
Accession:
GSM5008102
ID:
305008102
6.

L3 Large tumor

Organism:
Mus musculus
Source name:
B16 melanoma
Platform:
GPL6887
Series:
GSE164357
Download data
Sample
Accession:
GSM5008101
ID:
305008101
7.

L2 Large tumor

Organism:
Mus musculus
Source name:
B16 melanoma
Platform:
GPL6887
Series:
GSE164357
Download data
Sample
Accession:
GSM5008100
ID:
305008100
8.

L1 Large tumor

Organism:
Mus musculus
Source name:
B16 melanoma
Platform:
GPL6887
Series:
GSE164357
Download data
Sample
Accession:
GSM5008099
ID:
305008099
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Supplemental Content

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