(Submitter supplied) In germ cells, Piwi proteins interact with a specific class of small non-coding RNAs, piwi-interacting RNAs (piRNAs). Together, these form a pathway that represses transposable elements, thus safeguarding germ cell genomes. While basic models describe the operation of piRNA pathways, neither the protein compositions of Piwi complexes, the critical protein-protein interactions that drive small RNA production and target recognition, or the precise molecular consequences of conserved localization to germline structures, call nuage, is well understood.
more...- Organism:
- Mus musculus
- Type:
- Non-coding RNA profiling by high throughput sequencing
- Platform:
- GPL9185
- 8 Samples
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