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Items: 1 to 20 of 109

1.

Chromatin accessibility mapping at schizophrenia GWAS risk loci reveals compound genetic effects impairing neurodevelopment and synaptic function in human neurons

(Submitter supplied) Here, in NEUROG2-induced human neurons, we identified 31 credible risk SNPs in 26 schizophrenia (SZ) risk loci that displayed allele-specific open chromatin (ASoC) and were likely to be functional. For the VPS45 locus showing the strongest ASoC, CRISPR/Cas9 editing of ASoC SNP (rs2027349) altered the local expression of VPS45 and AC244033.2 (a lncRNA), and a distal gene, C1orf54. Notably, the global expression changes in neurons correlated with post-mortem brain expression signatures of neuropsychiatric disorders. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11154 GPL24676
106 Samples
Download data: BAM, NARROWPEAK, TAR, TXT
Series
Accession:
GSE188491
ID:
200188491
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

H12-sg-3_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474397
ID:
307474397
5.

H12-sg-2_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474396
ID:
307474396
6.

H12-sg-1_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474395
ID:
307474395
7.

H12-EGFP-3_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474394
ID:
307474394
8.

H12-EGFP-2_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474393
ID:
307474393
9.

H12-EGFP-1_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474392
ID:
307474392
10.

B11-EGFP-3_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474391
ID:
307474391
11.

B11-EGFP-2_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474390
ID:
307474390
12.

B11-EGFP-1_batch2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474389
ID:
307474389
13.

H6-EGFP-3

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474388
ID:
307474388
14.

H6-EGFP-2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474387
ID:
307474387
15.

H6-EGFP-1

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474386
ID:
307474386
16.

H12-VPS45-3

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474385
ID:
307474385
17.

H12-VPS45-2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474384
ID:
307474384
18.

H12-VPS45-1

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474383
ID:
307474383
19.

H12-lncRNA-3

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474382
ID:
307474382
20.

H12-lncRNA-2

Organism:
Homo sapiens
Source name:
81566
Platform:
GPL11154
Series:
GSE188491
Download data
Sample
Accession:
GSM7474381
ID:
307474381
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Supplemental Content

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