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Items: 11

1.

Integrator endonuclease drives promoter-proximal termination at all RNAPII transcribed loci (RNA-Seq)

(Submitter supplied) Pausing of RNA polymerase II (RNAPII) in early elongation is critical for gene regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb or targeted for premature termination by the Integrator complex. Integrator comprises endonuclease and phosphatase activities, driving termination through cleavage of nascent RNA and removal of stimulatory phosphorylation. To probe the direct consequences of Integrator activity, we generated a degron system to rapidly deplete the Integrator endonuclease INTS11. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL24247
8 Samples
Download data: BW
Series
Accession:
GSE200699
ID:
200200699
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

siINTS11 RNA-seq Rep 3

Organism:
Mus musculus
Source name:
Embryonic stem cell
Platform:
GPL24247
Series:
GSE200699 GSE200702
Download data
Sample
Accession:
GSM6042445
ID:
306042445
5.

siINTS11 RNA-seq Rep 2

Organism:
Mus musculus
Source name:
Embryonic stem cell
Platform:
GPL24247
Series:
GSE200699 GSE200702
Download data
Sample
Accession:
GSM6042444
ID:
306042444
6.

siINTS11 RNA-seq Rep 1

Organism:
Mus musculus
Source name:
Embryonic stem cell
Platform:
GPL24247
Series:
GSE200699 GSE200702
Download data
Sample
Accession:
GSM6042443
ID:
306042443
7.

siNT RNA-seq Rep 3

Organism:
Mus musculus
Source name:
Embryonic stem cell
Platform:
GPL24247
Series:
GSE200699 GSE200702
Download data
Sample
Accession:
GSM6042442
ID:
306042442
8.

siNT RNA-seq Rep 2

Organism:
Mus musculus
Source name:
Embryonic stem cell
Platform:
GPL24247
Series:
GSE200699 GSE200702
Download data
Sample
Accession:
GSM6042441
ID:
306042441
9.

siNT RNA-seq Rep 1

Organism:
Mus musculus
Source name:
Embryonic stem cell
Platform:
GPL24247
Series:
GSE200699 GSE200702
Download data
Sample
Accession:
GSM6042440
ID:
306042440
10.

WT RNA-seq Rep 2

Organism:
Mus musculus
Source name:
Embryonic stem cell
Platform:
GPL19057
Series:
GSE200699 GSE200702
Download data
Sample
Accession:
GSM6042439
ID:
306042439
11.

WT RNA-seq Rep 1

Organism:
Mus musculus
Source name:
Embryonic stem cell
Platform:
GPL19057
Series:
GSE200699 GSE200702
Download data
Sample
Accession:
GSM6042438
ID:
306042438
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Supplemental Content

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