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Items: 6

1.

IRX5 promotes DNA damage repair and activation of hair follicle stem cells [ATAC-Seq]

(Submitter supplied) Here, we identify the transcription factor IRX5 as a promoter of HFSC activation. Irx5-/- mice display delayed onset of first postnatal anagen, with increased DNA damage and diminished HFSC proliferation. Through transcriptomic and epigenetic analysis, we discover the formation of open chromatin regions near key cell cycle progression- and DNA damage repair genes in Irx5-/- HFSC. We also identify DNA damage repair factors BRCA1 and BARD1 as IRX5 downstream targets. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: BED
Series
Accession:
GSE202085
ID:
200202085
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

WT_rep2 [ATAC-Seq]

Organism:
Mus musculus
Source name:
hair follicle stem cell
Platform:
GPL17021
Series:
GSE202076 GSE202085
Download data
Sample
Accession:
GSM6094266
ID:
306094266
4.

Irx5KO_rep2 [ATAC-Seq]

Organism:
Mus musculus
Source name:
hair follicle stem cell
Platform:
GPL17021
Series:
GSE202076 GSE202085
Download data
Sample
Accession:
GSM6094265
ID:
306094265
5.

WT_rep1 [ATAC-Seq]

Organism:
Mus musculus
Source name:
hair follicle stem cell
Platform:
GPL17021
Series:
GSE202076 GSE202085
Download data
Sample
Accession:
GSM6094264
ID:
306094264
6.

Irx5KO_rep1 [ATAC-Seq]

Organism:
Mus musculus
Source name:
hair follicle stem cell
Platform:
GPL17021
Series:
GSE202076 GSE202085
Download data
Sample
Accession:
GSM6094263
ID:
306094263
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Supplemental Content

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