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Items: 8

1.

RNA-seq analysis of mouse esophageal tissue following GITR agonism in a model of esophageal squamous cell cancer

(Submitter supplied) Immune checkpoint modulation is an emerging therapeutic strategy for the treatment of esophageal squamous cell cancer (ESCC), but current strategies only benefit a fraction of patients. Glucocorticoid-induced TNFR-related protein (GITR) is a costimulatory immune checkpoint molecule that, upon engagement, can induce anti-tumor activity in solid tumor models. Here, we performed RNA sequencing analysis following targeting of GITR with an agonist antibody (clone DTA-1) or isotype control in the 4-nitroquinoline-1-oxide (4-NQO) mouse model of ESCC.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
6 Samples
Download data: TXT
Series
Accession:
GSE202545
ID:
200202545
2.

Illumina HiSeq 4000 (Mus musculus)

Platform
Accession:
GPL21103
ID:
100021103
3.

4-NQO + DTA-1 rep3

Organism:
Mus musculus
Source name:
esophagus enriched for invading cells
Platform:
GPL21103
Series:
GSE202545
Download data: TXT
Sample
Accession:
GSM6124230
ID:
306124230
4.

4-NQO + DTA-1 rep2

Organism:
Mus musculus
Source name:
esophagus enriched for invading cells
Platform:
GPL21103
Series:
GSE202545
Download data: TXT
Sample
Accession:
GSM6124229
ID:
306124229
5.

4-NQO + DTA-1 rep1

Organism:
Mus musculus
Source name:
esophagus enriched for invading cells
Platform:
GPL21103
Series:
GSE202545
Download data: TXT
Sample
Accession:
GSM6124228
ID:
306124228
6.

4-NQO + isotype control rep3

Organism:
Mus musculus
Source name:
esophagus enriched for invading cells
Platform:
GPL21103
Series:
GSE202545
Download data: TXT
Sample
Accession:
GSM6124227
ID:
306124227
7.

4-NQO + isotype control rep2

Organism:
Mus musculus
Source name:
esophagus enriched for invading cells
Platform:
GPL21103
Series:
GSE202545
Download data: TXT
Sample
Accession:
GSM6124226
ID:
306124226
8.

4-NQO + isotype control rep1

Organism:
Mus musculus
Source name:
esophagus enriched for invading cells
Platform:
GPL21103
Series:
GSE202545
Download data: TXT
Sample
Accession:
GSM6124225
ID:
306124225
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Supplemental Content

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