GSE21143[Accession] - GEO DataSets

Select item 2000211431.

PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma

(Submitter supplied) A hallmark feature of glioblastoma (GBM) cells is its strong self-renewal potential and immature differentiation state -- stem cell-like properties which may contribute to the plasticity and intense therapeutic resistance of GBM. The molecular basis of the immature differentiation profile remains an area of active investigation. Here, integrated genomic and biological analyses identified PLAGL2 as a potent proto-oncogene targeted for amplification/gain in malignant gliomas as well as in colorectal cancers. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3767
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE21143

ID:: 200021143

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 37672.

Zinc finger transcription factor PLAGL2 effect on primary p53-null neural stem cells

Analysis of PlagL2-transduced, p53-null neural stem cells (NSCs) following differentiation induction. PLAGL2 strongly suppresses NSC differentiation while promoting self-renewal capacity. Results provide insight into the molecular basis of this differentiation-suppressive activity.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL1261
Series:: GSE21143
6 Samples

Download data: CEL

DataSet

Accession:: GDS3767

ID:: 3767

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...