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Items: 8

1.

RCCD1 also Resides in Mitochondria to Regulate mtDNA Dynamics and Mitochondrial Homeostasis

(Submitter supplied) Regulator of chromosome condensation domain-containing protein 1 (RCCD1) plays an important role in chromosome segregation and microtubule stability in the nucleus and has been identified recently as a potential driver for breast cancer. We report here that, unexpectedly, RCCD1 is also localized in mitochondria. We show that RCCD1 resides in the mitochondrial inner membrane, where it interacts with the mitochondrial contact site/cristae organizing system (MICOS) and mitochondrial DNA (mtDNA) to regulate mitochondrial nucleoid organization, thereby influencing mtDNA transcription, oxidative phosphorylation, and the production of reactive oxygen species. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: CSV
Series
Accession:
GSE219134
ID:
200219134
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

RCCD1_replication_3

Organism:
Homo sapiens
Source name:
MCF-7 cells
Platform:
GPL16791
Series:
GSE219134
Download data: CSV
Sample
Accession:
GSM6774451
ID:
306774451
4.

RCCD1_replication_2

Organism:
Homo sapiens
Source name:
MCF-7 cells
Platform:
GPL16791
Series:
GSE219134
Download data: CSV
Sample
Accession:
GSM6774450
ID:
306774450
5.

RCCD1_replication_1

Organism:
Homo sapiens
Source name:
MCF-7 cells
Platform:
GPL16791
Series:
GSE219134
Download data: CSV
Sample
Accession:
GSM6774449
ID:
306774449
6.

Vector_replication_3

Organism:
Homo sapiens
Source name:
MCF-7 cells
Platform:
GPL16791
Series:
GSE219134
Download data: CSV
Sample
Accession:
GSM6774448
ID:
306774448
7.

Vector_replication_2

Organism:
Homo sapiens
Source name:
MCF-7 cells
Platform:
GPL16791
Series:
GSE219134
Download data: CSV
Sample
Accession:
GSM6774447
ID:
306774447
8.

Vector_replication_1

Organism:
Homo sapiens
Source name:
MCF-7 cells
Platform:
GPL16791
Series:
GSE219134
Download data: CSV
Sample
Accession:
GSM6774446
ID:
306774446
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Supplemental Content

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