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Items: 8

1.

PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer [RNA-seq]

(Submitter supplied) The promyelocytic leukemia (PML) protein organizes nuclear aggregates known as PML nuclear bodies (PML-NBs), where many transcription factors and transcriptional regulators converge to be regulated. Specific associations of PML and PML-NBs with chromatin are described in different cell types, further implicating PML in transcriptional regulation. However, a complete understanding of the functional consequences of PML association to DNA in a cellular context where it regulates relevant phenotypes is still lacking.We examined the role of PML in chromatin association and transcription in triple-negative breast cancer (TNBC), a pathological condition where PML exerts important oncogenic functions. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
6 Samples
Download data: TXT
Series
Accession:
GSE226111
ID:
200226111
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

PML knockdown, MDA231, rep3

Organism:
Homo sapiens
Source name:
MDA-MB-231
Platform:
GPL24676
Series:
GSE226111 GSE226210
Download data
Sample
Accession:
GSM7064264
ID:
307064264
4.

PML knockdown, MDA231, rep2

Organism:
Homo sapiens
Source name:
MDA-MB-231
Platform:
GPL24676
Series:
GSE226111 GSE226210
Download data
Sample
Accession:
GSM7064263
ID:
307064263
5.

PML knockdown, MDA231, rep1

Organism:
Homo sapiens
Source name:
MDA-MB-231
Platform:
GPL24676
Series:
GSE226111 GSE226210
Download data
Sample
Accession:
GSM7064262
ID:
307064262
6.

control, MDA231, rep3

Organism:
Homo sapiens
Source name:
MDA-MB-231
Platform:
GPL24676
Series:
GSE226111 GSE226210
Download data
Sample
Accession:
GSM7064261
ID:
307064261
7.

control, MDA231, rep2

Organism:
Homo sapiens
Source name:
MDA-MB-231
Platform:
GPL24676
Series:
GSE226111 GSE226210
Download data
Sample
Accession:
GSM7064260
ID:
307064260
8.

control, MDA231, rep1

Organism:
Homo sapiens
Source name:
MDA-MB-231
Platform:
GPL24676
Series:
GSE226111 GSE226210
Download data
Sample
Accession:
GSM7064259
ID:
307064259
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Supplemental Content

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