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Items: 14

1.

Mitochondrial complex I activity in microglia sustains neuroinflammation [bulk]

(Submitter supplied) Sustained smouldering, or low grade, activation of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple sclerosis (MS). Distinct metabolic and mitochondrial features guide the activation and the diverse functional states of myeloid cells. However, how these metabolic features act to perpetuate neuroinflammation is currently unknown. Using a multiomics approach, we identified a new molecular signature that perpetuates the activation of myeloid cells through mitochondrial complex I (CI) activity driving reverse electron transport (RET) and the production of reactive oxygen species (ROS). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
12 Samples
Download data: TXT
Series
Accession:
GSE248170
ID:
200248170
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

PIMP_4

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906786
ID:
307906786
4.

PIMP_3

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906785
ID:
307906785
5.

PIMP_2

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906784
ID:
307906784
6.

PIMP_1

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906783
ID:
307906783
7.

MG_4

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906782
ID:
307906782
8.

MG_3

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906781
ID:
307906781
9.

MG_2

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906780
ID:
307906780
10.

MG_1

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906779
ID:
307906779
11.

IPS_4

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906778
ID:
307906778
12.

IPS_3

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906777
ID:
307906777
13.

IPS_2

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906776
ID:
307906776
14.

IPS_1

Organism:
Homo sapiens
Source name:
cells
Platform:
GPL24676
Series:
GSE248170 GSE248175
Download data
Sample
Accession:
GSM7906775
ID:
307906775
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Supplemental Content

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