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Items: 10

1.

Claudin-7 knockout by gene targeting

(Submitter supplied) To investigate the claudin-7 function in vivo, we generated a claudin-7 knockout mouse model by gene targeting through homologous recombination. In this study, we report that Cln7-/- pups show Na+, Cl-, and K+ wasting and chronic dehydration phenotypes. The dramatic increase of aldosterone synthase mRNA level suggests that these mice suffer from mishandling of NaCl and fluid in the distal nephrons. Deletion of claudin-7 invokes several compensatory changes, such as increased renin, serum-glucocorticoid-induced kinase 1 (SGK1), epithelial Na+ channel (ENaCα), Na+-Cl- cotransporter (NCC), as well as aquaporin (AQP) 2 mRNA levels, demonstrating the cross talks between paracellular and transcellular ion transport pathways.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
8 Samples
Download data: TXT
Series
Accession:
GSE256329
ID:
200256329
2.

Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version)

(Submitter supplied) SurePrint G3 Mouse GE 8x60K Microarray Glass slide formatted with eight high-definition 60K arrays Includes probes for mRNAs and lincRNAs (long intergenic non-coding RNAs) 60-mer oligo probes *** The ID column includes the Agilent Probe Names. A different version of this platform with the Agilent Feature Extraction feature numbers in the ID column is assigned accession number GPL13912. Protocol: see manufacturer's web site www.chem.agilent.com
Organism:
Mus musculus
685 Series
1 Related Platform
10236 Samples
Download data
Platform
Accession:
GPL10787
ID:
100010787
3.

#3 KO large intestine

Organism:
Mus musculus
Source name:
KO large intestines
Platform:
GPL10787
Series:
GSE256329
Download data: TXT
Sample
Accession:
GSM8093811
ID:
308093811
4.

#3 WT large intestine

Organism:
Mus musculus
Source name:
WT large intestines
Platform:
GPL10787
Series:
GSE256329
Download data: TXT
Sample
Accession:
GSM8093810
ID:
308093810
5.

#3 KO small intestine

Organism:
Mus musculus
Source name:
KO small intestines
Platform:
GPL10787
Series:
GSE256329
Download data: TXT
Sample
Accession:
GSM8093809
ID:
308093809
6.

#3 WT small intestine

Organism:
Mus musculus
Source name:
WT small intestines
Platform:
GPL10787
Series:
GSE256329
Download data: TXT
Sample
Accession:
GSM8093808
ID:
308093808
7.

#2 KO large intestine

Organism:
Mus musculus
Source name:
KO large intestines
Platform:
GPL10787
Series:
GSE256329
Download data: TXT
Sample
Accession:
GSM8093807
ID:
308093807
8.

#2 WT large intestine

Organism:
Mus musculus
Source name:
WT large intestines
Platform:
GPL10787
Series:
GSE256329
Download data: TXT
Sample
Accession:
GSM8093806
ID:
308093806
9.

#2 KO small intestine

Organism:
Mus musculus
Source name:
KO small intestines
Platform:
GPL10787
Series:
GSE256329
Download data: TXT
Sample
Accession:
GSM8093805
ID:
308093805
10.

#2 WT small intestine

Organism:
Mus musculus
Source name:
WT small intestines
Platform:
GPL10787
Series:
GSE256329
Download data: TXT
Sample
Accession:
GSM8093804
ID:
308093804
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Supplemental Content

db=gds|term=GSE256329[Accession]|query=1|qty=2|blobid=MCID_664c794b8e57fe2577586cac|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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