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Items: 4

1.

KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation [RNA-Seq]

(Submitter supplied) Pluripotency of embryonic stem (ES) cells is controlled in part by chromatin-modifying factors that regulate histone H3 lysine 4 (H3K4) methylation. However, it remains unclear how H3K4 demethylation contributes to ES cell function. Here, we show that KDM5B, which demethylates lysine 4 of histone H3, co-localizes with H3K4me3 near promoters and enhancers of active genes in ES cells; its depletion leads to spreading of H3K4 methylation into gene bodies and enhancer shores, indicating that KDM5B functions to focus H3K4 methylation at promoters and enhancers. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: BED, BEDGRAPH, RPKM
Series
Accession:
GSE53090
ID:
200053090
2.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
3.

mES_shKdm5b

Organism:
Mus musculus
Source name:
shKdm5b ES cells
Platform:
GPL13112
Series:
GSE53090 GSE53093
Download data: BED, BEDGRAPH, RPKM
Sample
Accession:
GSM1282304
ID:
301282304
4.

mES_shLuc_ctrl

Organism:
Mus musculus
Source name:
shLuc ES cells
Platform:
GPL13112
Series:
GSE53090 GSE53093
Download data: BED, BEDGRAPH, RPKM
Sample
Accession:
GSM1282302
ID:
301282302
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Supplemental Content

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