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Items: 5

1.

Targeting the NF-κB signaling pathway in Notch1-induced T cell leukemia

(Submitter supplied) T cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that the majority of TALL patients carry activating mutations in the NOTCH1 gene. However, the signaling pathways and target genes responsible for Notch1-induced neoplastic transformation remain undefined. We report here that constitutively-active Notch1 activates the NF-κB pathway transcriptionally and via the IκB kinase (IKK) complex, thereby causing increased expression of multiple well-characterized NF-κB target genes in bone marrow hematopoietic stem cells and progenitors. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4596
3 Samples
Download data: TXT
Series
Accession:
GSE6396
ID:
200006396
2.

Vilimas (Agilent Mouse Microarray G4121A)

(Submitter supplied) This is a custom representation of Agilent's Mouse Microarray G4121A This platform is formatted specifically for this user's normalized data and should not be referenced by other users. Protocol: see manufacturer's web site at http://www.agilent.com/
Organism:
Mus musculus
1 Series
3 Samples
Download data
Platform
Accession:
GPL4596
ID:
100004596
3.

Notch1-IC-expressing BM progenitors vs Notch1-IC-expressing BM progenitors cultured on OP9-DL1 stroma

Organism:
Mus musculus
Source name:
bone marrow lineage-negative progenitors carrying a Notch1-IC retrovirus, 4 days (channel 1) bone marrow lineage-negative progenitors carrying a Notch1-IC retrovirus, cultured on OP9-DL1 stroma (channel 2)
Platform:
GPL4596
Series:
GSE6396
Download data: TXT
Sample
Accession:
GSM147508
ID:
300147508
4.

EGFP-expressing BM progenitors vs Notch1-IC-expressing BM progenitors cultured on OP9-DL1 stroma

Organism:
Mus musculus
Source name:
bone marrow lineage-negative progenitors carrying a EGFP retrovirus, 4 days (channel 1) bone marrow lineage-negative progenitors carrying a Notch1-IC retrovirus, cultured on OP9-DL1 stroma (channel 2)
Platform:
GPL4596
Series:
GSE6396
Download data: TXT
Sample
Accession:
GSM147464
ID:
300147464
5.

EGFP-expressing BM progenitors vs Notch1-IC-expressing BM progenitors

Organism:
Mus musculus
Source name:
bone marrow lineage-negative progenitors carrying a EGFP retrovirus, 4 days (channel 1) bone marrow lineage-negative progenitors carrying a Notch1-IC retrovirus, 4 days (channel 2)
Platform:
GPL4596
Series:
GSE6396
Download data: TXT
Sample
Accession:
GSM147443
ID:
300147443
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Supplemental Content

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