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Items: 14

1.

Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity

(Submitter supplied) Metabolomics studies of human plasma demonstrate a correlation of lower plasma lysophosphatidylcholines (LPC) concentrations with insulin resistance, obesity, and inflammation. This relationship is not unraveled on a molecular level. Here we investigated the effects of the abundant LPC(16:0) and LPC(18:1) on human skeletal muscle cells differentiated to myotubes. Transcriptome analysis of human myotubes treated with 10 µM LPC for 24 h revealed enrichment of up-regulated peroxisome proliferator-activated receptor (PPAR) target transcripts, including ANGPTL4, PDK4, PLIN2, and CPT1A. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
12 Samples
Download data: CEL
Series
Accession:
GSE77337
ID:
200077337

Analyze with GEO2R

2.

[HG-U219] Affymetrix Human Genome U219 Array

(Submitter supplied) see manufacturer's website
Organism:
Homo sapiens
219 Series
10 Related Platforms
20079 Samples
Download data
Platform
Accession:
GPL13667
ID:
100013667

3.

Donor#4 LPC(18:1)

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #4
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049417
ID:
302049417

4.

Donor#4 LPC(16:0)

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #4
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049416
ID:
302049416

5.

Donor#4 con

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #4
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049415
ID:
302049415

6.

Donor#3 LPC(18:1)

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #3
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049414
ID:
302049414

7.

Donor#3 LPC(16:0)

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #3
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049413
ID:
302049413

8.

Donor#3 con

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #3
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049412
ID:
302049412

9.

Donor#2 LPC(18:1)

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #2
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049411
ID:
302049411

10.

Donor#2 LPC(16:0)

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #2
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049410
ID:
302049410

11.

Donor#2 con

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #2
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049409
ID:
302049409

12.

Donor#1 LPC(18:1)

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #1
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049408
ID:
302049408

13.

Donor#1 LPC(16:0)

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #1
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049407
ID:
302049407

14.

Donor#1 con

Organism:
Homo sapiens
Source name:
human primary myotubes from donor #1
Platform:
GPL13667
Series:
GSE77337
Download data: CEL
Sample
Accession:
GSM2049406
ID:
302049406

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