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Items: 9

1.

A Pro-Asthmatic IL-4 Receptor Allele Promotes Airway Inflammation by Programming TH17 Cell-Like Regulatory T cells

(Submitter supplied) Mechanisms by which regulatory T (Treg) cells fail to control inflammation in asthma remain poorly understood. We show that a severe asthma-associated polymorphism in the interleukin-4 receptor alpha chain (IL-4Rα-R576) biases induced Treg (iTreg) cells towards a T helper 17 (TH17) cell fate. This skewing reflects the recruitment by IL-4Rα-R576 of the adaptor protein growth factor receptor-bound protein 2 (GRB2), which drives IL-17 expression by an extracellular signal-regulated kinase-, IL-6- and STAT3-dependent mechanism. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
7 Samples
Download data: TXT
Series
Accession:
GSE80804
ID:
200080804
2.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
3.

CCR6–Foxp3EGFP+ Il4raR576 Treg 4

Organism:
Mus musculus
Source name:
CCR6–Foxp3EGFP+ Il4raR576 Treg
Platform:
GPL21493
Series:
GSE80804
Download data: TXT
Sample
Accession:
GSM2137742
ID:
302137742
4.

CCR6–Foxp3EGFP+ Il4raR576 Treg 3

Organism:
Mus musculus
Source name:
CCR6–Foxp3EGFP+ Il4raR576 Treg
Platform:
GPL21493
Series:
GSE80804
Download data: TXT
Sample
Accession:
GSM2137741
ID:
302137741
5.

CCR6–Foxp3EGFP+ Il4raR576 Treg 2

Organism:
Mus musculus
Source name:
CCR6–Foxp3EGFP+ Il4raR576 Treg
Platform:
GPL21493
Series:
GSE80804
Download data: TXT
Sample
Accession:
GSM2137740
ID:
302137740
6.

CCR6–Foxp3EGFP+ Il4raR576 Treg 1

Organism:
Mus musculus
Source name:
CCR6–Foxp3EGFP+ Il4raR576 Treg
Platform:
GPL21493
Series:
GSE80804
Download data: TXT
Sample
Accession:
GSM2137739
ID:
302137739
7.

CCR6+Foxp3EGFP+ Il4raR576 Treg 3

Organism:
Mus musculus
Source name:
CCR6+Foxp3EGFP+ Il4raR576 Treg
Platform:
GPL21493
Series:
GSE80804
Download data: TXT
Sample
Accession:
GSM2137738
ID:
302137738
8.

CCR6+Foxp3EGFP+ Il4raR576 Treg 2

Organism:
Mus musculus
Source name:
CCR6+Foxp3EGFP+ Il4raR576 Treg
Platform:
GPL21493
Series:
GSE80804
Download data: TXT
Sample
Accession:
GSM2137737
ID:
302137737
9.

CCR6+Foxp3EGFP+ Il4raR576 Treg 1

Organism:
Mus musculus
Source name:
CCR6+Foxp3EGFP+ Il4raR576 Treg
Platform:
GPL21493
Series:
GSE80804
Download data: TXT
Sample
Accession:
GSM2137736
ID:
302137736
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Supplemental Content

db=gds|term=GSE80804[Accession]|query=1|qty=2|blobid=MCID_664debc48e57fe25777d2d8b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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