GEO DataSets

(Submitter supplied) Endotoxin/LPS tolerance is a tightly regulated phenomenon, which, during infection, prevents systemic hyper-inflammation. Here we report for the first time that morphine reversal of endotoxin tolerance resulting in persistent inflammation thus contributing to septicemia and septic shock. We further report that this regulation is mediated by LPS-induced down-regulation of microRNAs 146a and 155. However, only over-expression of miR-146a, but not miR-155 abrogates morphine mediated hyper-inflammation, while antagonizing miR-146a (but not miR-155) augments morphine mediated hyper-inflammation. more...

Organism:

Homo sapiens; Caenorhabditis elegans; Drosophila melanogaster; Mus musculus; Rattus norvegicus; Danio rerio

Type:

Non-coding RNA profiling by array

Platform:

GPL15559

6 Samples

Download data: TXT

(Submitter supplied) A miRNA probe set was purchased from Invitrogen, which was designed based on the Sanger miRBase Sequence Database, Release 9.0. The set contains approximately 1,140 oligonucleotides of 34 to 44 nt long as probes. They are complementary to C. elegans, Drosophila, zebrafish, mouse, rat, and human miRNAs, and also include a number of internal and negative control probes. The oligonucleotides were dissolved in 3 x SSC and quadruply printed on Corning® GAPSTM II coated slides using a BioRobotics Microgrid II spotter

Organism:

Caenorhabditis elegans; Drosophila melanogaster; Danio rerio; Homo sapiens; Mus musculus; Rattus norvegicus

2 Series

8 Samples

Download data