GEO DataSets

(Submitter supplied) DNA methylation can contribute to the stable transcriptional silencing of mammalian genes. Oftentimes, these genes are important developmental regulators, and their silencing in cell types where they are not supposed to be active is important for the phenotypic stability of the cells. To identify key developmental regulator genes whose expression in terminally differentiated cells may be inhibited by DNA methylation, mouse dermal fibroblasts were demethylated with 5-aza-2’-deoxycytidine, and changes in gene expression monitored by microarray analysis. more...

Organism:

Mus musculus

Type:

Expression profiling by array; Methylation profiling by array

Dataset:

GDS2091

Platform:

GPL1261

18 Samples

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Analysis of chondrocytes, fibroblasts, and osteoblasts treated with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-aza-2dC). DNA methylation contributes to transcriptional silencing. Results identify genes whose expression is inhibited by DNA methylation in terminally differentiated cells.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 cell type sets

Platform:

GPL1261

Series:

GSE4768

18 Samples

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(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4544 Series

40 Related Platforms

58935 Samples

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