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Items: 4

1.

C/EBPα poises B cells for rapid reprogramming into iPS cells

(Submitter supplied) C/EBPα induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBPα accomplishes these effects is unclear. We now found that transient C/EBPα expression followed by OSKM activation induces a 100 fold increase in iPSC reprogramming efficiency, involving 95% of the cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL13912
48 Samples
Download data: BED, TSV, TXT
Series
Accession:
GSE52397
ID:
200052397
2.

C/EBPα poises B cells for rapid reprogramming into iPS cells [array]

(Submitter supplied) Somatic cell reprogramming into pluripotent stem cells induced by Oct4, Sox2, Klf4 and Myc (OSKM) occurs at low frequencies and with a considerable delay involving a stochastic phase. In contrast, transdifferentiation of B cells into macrophages induced by C/EBPα is fully efficient and initiated almost immediately. We now discovered that a pulse of C/EBPα in B cell precursors followed by OSKM expression dramatically enhances reprogramming to pluripotency, overcoming the stochastic phase. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
44 Samples
Download data: TXT
Series
Accession:
GSE46321
ID:
200046321
3.

Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version)

(Submitter supplied) Design ID: 028005 Build version: mm9:NCBI37:Jul2007 Arrays of this design have barcodes that begin with 16028005 or 2528005. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Feature Extraction feature number. more...
Organism:
Mus musculus
473 Series
1 Related Platform
5679 Samples
Download data: TXT
Platform
Accession:
GPL13912
ID:
100013912
4.

B cells, time 144, technical replicate 1

Organism:
Mus musculus
Source name:
T144
Platform:
GPL13912
Series:
GSE46321 GSE52397
Download data: TXT
Sample
Accession:
GSM1128635
ID:
301128635
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db=gds|term=GSM1128635[Accession]|query=1|qty=2|blobid=MCID_66747efb8c5d4760e2a83a81|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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