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Items: 4

1.

Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
5 related Platforms
70 Samples
Download data: CEL, TXT
Series
Accession:
GSE43900
ID:
200043900
2.

Co-ordinate inhibiton of autism candidate genes by topoisomerase inhibitors [array]

(Submitter supplied) Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomerases selectively inhibit long genes (>100kb), with little effect on all other gene expression. Using ChIPseq against RNA Polymerase II (Pol2) we show that the Top1 inhibitor topotecan blocks transcriptional elongation of long genes specifically. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1261 GPL17400 GPL11533
56 Samples
Download data: CEL
Series
Accession:
GSE43899
ID:
200043899
3.

[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html MoGene-1_1-st-v1.na31.mm9.transcript.csv #%create_date=Fri Aug 27 17:50:02 2010 PDT #%chip_type=MoGene-1_1-st-v1 #%lib_set_name=MoGene-1_1-st #%lib_set_version=v1 #%genome-species=Mus musculus #%genome-version=mm9 #%genome-version-ucsc=mm9 #%genome-version-ncbi=37 #%genome-version-create_date=2007-07-00 #%genome-lifted-method=liftOver #%genome-lifted_from-species=Mus musculus #%genome-lifted_from-version-ucsc=mm8 #%genome-lifted_from-version-ncbi=36 #%netaffx-annotation-date=2010-07-15 #%netaffx-annotation-netaffx-build=31 Protocol: see manufacturer's web site
Organism:
Mus musculus
10 DataSets
174 Series
7 Related Platforms
4230 Samples
Download data
Platform
Accession:
GPL11533
ID:
100011533
4.

30nM_Topotecan

Organism:
Mus musculus
Source name:
cultured cortical neurons
Platform:
GPL11533
Series:
GSE43899 GSE43900
Download data: CEL
Sample
Accession:
GSM1179392
ID:
301179392
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