GSM1295050[Accession] - GEO DataSets

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Items: 4

Select item 2000535081.

PRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL11002
37 Samples

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Accession:: GSE53508

ID:: 200053508

PubMed Full text in PMC Similar studies

Select item 2000535062.

PRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (RNA-Seq)

(Submitter supplied) Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs to properly differentiate, which presents a major roadblock for dissecting the precise roles of PRC2 activity during lineage commitment. more...