GSM1327418[Accession] - GEO DataSets

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Items: 4

Select item 2000549791.

Targeting EZH2 methyltransferase activity in ARID1A mutated cells as a synthetic lethal therapeutic strategy

(Submitter supplied) ARID1A, an epigentic modifier, is often mutated in ovarian clear cell carcinoma (OCCC). In addition, EZH2 is frequently upregulated in OCCC. Inhibtion of EZH2 with an inhibitor (GSK126) selectively inhibits ARID1A-mutated cells. This study was designed to understand changes in gene expression profiles following EZH2 inhibition or ARID1A restoration.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5816
Platform:: GPL10558
9 Samples

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Series

Accession:: GSE54979

ID:: 200054979

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 58162.

Methyltransferase EZH2 inhibition effect on ARID1A mutated ovarian clear cell cancer cell line

Analysis of ARID1A-mutated OVISE ovarian clear cell carcinoma (OCCC) cells restored with wild-type ARID1A or treated with GSK126, an inhibitor of epigenetic regulator EZH2. Epigenetic modifier ARID1A is often mutated in OCCC. Results provide insight into the role of epigenetic mechanisms in OCCC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 genotype/variation sets

Platform:: GPL10558
Series:: GSE54979
9 Samples

Download data

DataSet

Accession:: GDS5816

ID:: 5816

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000105583.

Illumina HumanHT-12 V4.0 expression beadchip

(Submitter supplied) The HumanHT-12 v4 Expression BeadChip provides high throughput processing of 12 samples per BeadChip without the need for expensive, specialized automation. The BeadChip is designed to support flexible usage across a wide-spectrum of experiments. The updated content on the HumanHT-12 v4 Expression BeadChips provides more biologically meaningful results through genome-wide transcriptional coverage of well-characterized genes, gene candidates, and splice variants. more...