GEO DataSets

(Submitter supplied) Somatic mutations affecting DIS3, the catalytic component of the RNA exosome, have been found in up to 18% of patients affected by the hematological cancer multiple myeloma. Here we show that DIS3 targets and degrades the pluripotency factor LIN28B. In cancer cells, DIS3 inactivation leads to enhanced LIN28B expression, thus disrupting the let-7 miRNAs tumor suppressor network and ultimately increasing protein levels of crucial oncogenes such as MYC and RAS. more...

Organism:

Homo sapiens; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL8786

8 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html #%create_date=Tue Oct 21 17:29:14 PDT 2008 #%guid=0000050091-1224635354-0064538561-0684514888-1962062125 #%chip_type=miRNA-1_0 # File contains all miRNAs from miRBase that have mapping information grouped by organism, all miRNAs without mapping information grouped by organism (designated as Sequence Type: miRNA), all sno/sca from UCSC (snoRNABase) and Ensembl (designated as Sequence Type: CDBox, HAcaBox, snoRNA and scaRna, and controls). more...

Organism:

synthetic construct

200 Series

4415 Samples

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