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Items: 3

1.

The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis

(Submitter supplied) Despite correlations between histone methyltransferase (HMT) activity and gene regulation, direct evidence that HMT activity is responsible for gene activation is sparse. We address the role of the HMT activity for MLL1, a histone H3 lysine 4 (H3K4) methyltransferase critical for maintaining hematopoietic stem cells (HSCs). Here we show that the SET domain and thus HMT activity of MLL1 is dispensable for maintaining HSCs and for supporting leukemogenesis driven by the MLL-AF9 fusion oncoprotein. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
11 Samples
Download data: BW
Series
Accession:
GSE56456
ID:
200056456

SRA Run Selector

2.

Illumina HiSeq 2000 (Mus musculus)

Organism:
Mus musculus
8394 Series
189339 Samples
Download data
Platform
Accession:
GPL13112
ID:
100013112

3.

6.3_LSK_KO_H3K4me1

Organism:
Mus musculus
Source name:
sorted murine lin-/Sca-1/c-Kit in vitro cultured cells
Platform:
GPL13112
Series:
GSE56456
Download data: BW
Sample
Accession:
GSM1361802
ID:
301361802

SRA Run Selector

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db=gds|term=GSM1361802[Accession]|query=1|qty=2|blobid=MCID_679088dd3ebf2117044f1719|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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