GSM1581343[Accession] - GEO DataSets

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Items: 4

Select item 2000723001.

T-cell ALL in response to TAL1-KD, UTX-KD, and GSKJ4 treatment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Third-party reanalysis

Platform:: GPL11154
17 Samples

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Accession:: GSE72300

ID:: 200072300

PubMed Full text in PMC Similar studies

Select item 2000648322.

UTX inhibition as selective epigenetic therapy against TAL1-driven T cell acute lymphoblastic leukemia

(Submitter supplied) We performed ChIP-Seq in Jurkat T-ALL cells to identify UTX binding sites across the genome. We then compared UTX binding sites (this study) with TAL1 binding sites (Data from Palii, 2011 GSE25000), and found a high degree of overlap between TAL1 and UTX in Jurkat T-All cells. Indeed, over 80% of TAL1 binding sites overlap with UTX.