GSM1841089[Accession] - GEO DataSets

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Items: 4

Select item 2000715971.

Epigenetic profiling and RNA-sequencing of Juvenile Idiopathic Arthritits (JIA) patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
29 Samples

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Series

Accession:: GSE71597

ID:: 200071597

PubMed Similar studies

Select item 2000715962.

Epigenetic profiling of Juvenile Idiopathic Arthritits (JIA) patients

(Submitter supplied) With H3K27ac chromatin immunoprecipitation we identified a disease-specific, inflammation-associated, (super-)enhancer signature in JIA patient synovial fluid-derived CD4+ memory/effector T cells. This signature consists of unique pathogenesis-associated epigenetic changes which extend beyond general T cell activation-induced alterations, indicating that disease-specific (super-)enhancers contribute to JIA pathogenesis. more...