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Items: 4

1.

Functional interdependency of BRD4 and DOT1L in MLL leukaemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL11154
33 Samples
Download data: BED
Series
Accession:
GSE71780
ID:
200071780
2.

ChIPSeq of MV4;11 cell treated with DMSO, I-BET, SGC0946 and combination of I-BET and SGC0946

(Submitter supplied) Central to the molecular pathogenesis of MLL leukaemia is the abnormal co-optation of members of transcription complexes including disrupter of telomeric silencing 1-like (DOT1L) and bromodomain containing protein 4 (BRD4). Consequently, targeted therapies against DOT1L and BRD4 are currently being evaluated in clinical trials. However, the mechanisms by which BRD4 and DOT1L regulate leukaemogenic transcription programs remain unclear. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
16 Samples
Download data: BED
Series
Accession:
GSE71776
ID:
200071776
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

DMSO_H3K27ac_ChIP

Organism:
Homo sapiens
Source name:
MV4;11_DMSO_ChIP
Platform:
GPL11154
Series:
GSE71776 GSE71780
Download data: BED
Sample
Accession:
GSM1845134
ID:
301845134
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Supplemental Content

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