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Items: 4

1.

Reconstructing gene regulatory networks of tumorigenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; SNP genotyping by SNP array; Genome variation profiling by SNP array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL3718 GPL11154 GPL6244
27 Samples
Download data: BED, BW, CEL, WIG
Series
Accession:
GSE72533
ID:
200072533
2.

Reconstructing gene regulatory networks of tumorigenesis [ChIP-Seq]

(Submitter supplied) The mechanistic links between transcription factors and the epigenetic landscape, which coordinate the deregulation of gene networks during cell transformation are largely unknown. We used an isogenic model of stepwise tumorigenic transformation of human primary cells to monitor the progressive deregulation of gene networks upon immortalization and oncogene-induced transformation. By combining transcriptome and epigenome data for each step during transformation and by integrating transcription factor (TF) - target gene associations, we identified 142 TFs and 24 chromatin remodelers/modifiers (CRMs), which are preferentially associated with specific co-expression paths that originate from deregulated gene programming during tumorigenesis. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
18 Samples
Download data: BED, BW, WIG
Series
Accession:
GSE72532
ID:
200072532
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

BJELM_H3K4me3_ChIP-seq

Organism:
Homo sapiens
Source name:
Transformed BJELM fibroblast cells (cancer cells)
Platform:
GPL11154
Series:
GSE72532 GSE72533
Download data: BED, WIG
Sample
Accession:
GSM1869146
ID:
301869146
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