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Items: 4

1.

ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells

(Submitter supplied) ZFP57 is necessary for maintaining repressive epigenetic modifications at Imprinting control regions (ICRs). In mouse embryonic stem cells (ESCs), ZFP57 binds ICRs (ICRBS) and many other loci (non-ICRBS). To address the role of ZFP57 on all its target sites, we performed high-throughput and multi-locus analyses of inbred and hybrid mouse ESC lines carrying different gene knockouts. By using an allele-specific RNA-seq approach, we demonstrate that ZFP57 loss results in derepression of the imprinted allele of multiple genes in the imprinted clusters. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
23 Samples
Download data: BED, BEDGRAPH
Series
Accession:
GSE77444
ID:
200077444

PubMed Full text in PMC Similar studies

2.

ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells (ChIP-seq)

(Submitter supplied) ZFP57 is necessary for maintaining repressive epigenetic modifications at Imprinting control regions (ICRs). In mouse embryonic stem cells (ESCs), ZFP57 binds ICRs (ICRBS) and many other loci (non-ICRBS). To address the role of ZFP57 on all its target sites, we performed high-throughput and multi-locus analyses of inbred and hybrid mouse ESC lines carrying different gene knockouts. By using an allele-specific RNA-seq approach, we demonstrate that ZFP57 loss results in derepression of the imprinted allele of multiple genes in the imprinted clusters. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: BED, BEDGRAPH
Series
Accession:
GSE77440
ID:
200077440

PubMed Full text in PMC Similar studies SRA Run Selector

3.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11303 Series
302392 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

4.

A3 ZFP57 ChIP-seq

Organism:
Mus musculus
Source name:
A3
Platform:
GPL17021
Series:
GSE77440 GSE77444
Download data: BED, BEDGRAPH
Sample
Accession:
GSM2051867
ID:
302051867

SRA Run Selector

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db=gds|term=GSM2051867[Accession]|query=1|qty=2|blobid=MCID_67ad73f485cceb199536660f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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