GSM2125963[Accession] - GEO DataSets

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Items: 4

Select item 2000848831.

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schizosaccharomyces pombe

Type:: Other; Expression profiling by genome tiling array

Platforms:: GPL19654 GPL13988
16 Samples

Download data: BEDGRAPH, BW, TXT

Series

Accession:: GSE84883

ID:: 200084883

Select item 2000803982.

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(Submitter supplied) RNA-DNA hybrids are a major internal cause of DNA damage within cells, and their degradation by RNAse H enzymes is important for maintaining genomic stability. Here, we identified an unexpected role for RNA-DNA hybrids and RNase H enzymes in DNA repair. Using a site-specific DNA double-stranded break (DSB) system in Schizosaccharomyces pombe, we showed that RNA-DNA hybrids form as part of the homologous recombination (HR)-mediated DSB repair process and RNase H enzymes are essential for their degradation and efficient completion of DNA repair. more...