GSM2229467[Accession] - GEO DataSets

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Items: 4

Select item 2000842141.

BET inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: human gammaherpesvirus 4; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL23362 GPL22131 GPL22132
106 Samples

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Accession:: GSE84214

ID:: 200084214

PubMed Full text in PMC Similar studies

Select item 2000842122.

BET inhibitors suppress lytic DNA replication [Akata-Zta DNA-seq]

(Submitter supplied) Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. We demonstrate that JQ1 and other BET inhibitors block two different steps in the sequential cascade of the EBV life cycle: expression of the immediate-early gene BZLF1 and lytic genome replication. This represents a novel mode of action for antiviral drugs that may increase efficacy and decrease emergence of resistance. more...