GSM2326654[Accession] - GEO DataSets

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Items: 4

Select item 2000872821.

Conservation and innovation in the DUX4-family gene network

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Third-party reanalysis

Platform:: GPL17021
31 Samples

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Accession:: GSE87282

ID:: 200087282

PubMed Full text in PMC Similar studies

Select item 2000872662.

Conservation and innovation in the DUX4-family gene network (RNA-seq)

(Submitter supplied) Facioscapulohumeral dystrophy (FSHD; OMIM #158900, #158901) is caused by mis-expression of the DUX4 transcription factor in skeletal muscle1. Animal models of FSHD are hampered by incomplete knowledge of the conservation of the DUX4 transcriptional program in other species. Despite divergence of their binding motifs, both mouse Dux and human DUX4 activate genes associated with cleavage-stage embryos, including MERV-L and ERVL-MaLR retrotransposons, in mouse and human muscle cells respectively. more...