GEO DataSets

(Submitter supplied) Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age, as well as after recurrent demyelination. Using RNA-sequencing to compare the gene expression of fetal and adult hGPCs, we identify age-related changes in transcription consistent with the repression of genes enabling mitotic expansion, concurrent with the onset of aging-associated transcriptional programs. Adult hGPCs develop a repressive transcription factor network centered on MYC, and regulated by ZNF274, MAX, IKZF3, and E2F6. more...

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16384

8 Samples

Download data: CEL

(Submitter supplied) #%chip_type=miRNA-3_0 or miRNA-3_1 #%create_date=Mon Dec 3, 2012 # # miRNAs/stem-loops: # * An annot name generally represents one genome location, but may refer to multiple annotations because of multiple mature products delineated by "-3p" and "-5p", or ".1" and ".2". # * Also, those with a '-star' are minor products, and those without '-star' or any other aforementioned suffix are considered the major product. more...

Organism:

synthetic construct

198 Series

1 Related Platform

3450 Samples

Download data: CSV