GSM2966275[Accession] - GEO DataSets

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Items: 4

Select item 2001097471.

Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
68 Samples

Download data: COV

Series

Accession:: GSE109747

ID:: 200109747

PubMed Full text in PMC Similar studies

Select item 2001097452.

Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline [RNA-Seq]

(Submitter supplied) Maternal Vitamin C is required in vivo for proper DNA demethylation and development of fetal germ cells in a mouse model of Vitamin C deficiency. Withdrawal of Vitamin C from the maternal diet does not affect overall embryonic development but leads to defects in the fetal germline, which persist well after Vitamin C re-supply during late gestation. The transcriptome of germ cells from Vitamin C-deficient embryos is remarkably similar to that of embryos carrying a mutation in Tet1, which is responsible for DNA demethylation and activation of regulators of meiosis. more...