GSM3018252[Accession] - GEO DataSets

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Items: 3

Select item 2001108841.

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway

(Submitter supplied) Oncogenic signals can induce premature senescence (OIS) in normal human cells causing a proliferation arrest and the elimination of these defective cells by immune cells. In order to identify new regulators of OIS, we performed a loss-of-function genetic screen and identified that the loss of SCN9A sodium channel allowed cells to escape from OIS. Here we studied the transcriptome profiles of an OIS model based on human mammary epithelial cells stably expressing hTert to be immortalized and MEK:ER, a 4-hydroxytamoxifen (4-OHT) inducible oncogene MEK:ER (HEC-TM cells), to induce the oncogenic signal. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
15 Samples

Download data: TXT

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Accession:: GSE110884

ID:: 200110884

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000134972.

Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)

(Submitter supplied) *** The ID column includes the Agilent Probe Names. A different version of this platform with the Agilent Feature Extraction feature numbers in the ID column is assigned accession number GPL10332. Protocol: see manufacturer's web site at http://www.agilent.com/