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Items: 3

1.

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway

(Submitter supplied) Oncogenic signals can induce premature senescence (OIS) in normal human cells causing a proliferation arrest and the elimination of these defective cells by immune cells. In order to identify new regulators of OIS, we performed a loss-of-function genetic screen and identified that the loss of SCN9A sodium channel allowed cells to escape from OIS. Here we studied the transcriptome profiles of an OIS model based on human mammary epithelial cells stably expressing hTert to be immortalized and MEK:ER, a 4-hydroxytamoxifen (4-OHT) inducible oncogene MEK:ER (HEC-TM cells), to induce the oncogenic signal. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
15 Samples
Download data: TXT
Series
Accession:
GSE110884
ID:
200110884
2.

Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)

(Submitter supplied) *** The ID column includes the Agilent Probe Names. A different version of this platform with the Agilent Feature Extraction feature numbers in the ID column is assigned accession number GPL10332. Protocol: see manufacturer's web site at http://www.agilent.com/
Organism:
Homo sapiens
417 Series
1 Related Platform
7921 Samples
Download data
Platform
Accession:
GPL13497
ID:
100013497
3.

HEC-TM-OHT24h_R3

Organism:
Homo sapiens
Source name:
Mammary epithelial cells immortalized with hTERT treated with 4-OHT during 24 hours
Platform:
GPL13497
Series:
GSE110884
Download data: TXT
Sample
Accession:
GSM3018255
ID:
303018255
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db=gds|term=GSM3018255[Accession]|query=1|qty=2|blobid=MCID_6648b8963844a3792a3a1d1f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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