GSM3020584[Accession] - GEO DataSets

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Items: 4

Select item 2001110271.

Single-cell RNA sequencing unveils a unique IL-10-producing T follicular helper subset that sustains humoral immunity during chronic viral infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

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Series

Accession:: GSE111027

ID:: 200111027

PubMed Full text in PMC Similar studies

Select item 2001110252.

RNA-seq of Tfh IL21+ single producers and Tfh IL21+ IL10+ double producers

(Submitter supplied) During chronic viral infection, the inflammatory function of CD4 T cells becomes gradually attenuated. Concurrently, Th1 cells progressively acquire the capacity to secrete the cytokine IL-10, a potent suppressor of antiviral T cell responses. To determine the transcriptional changes that underlie this T cell adaption process, we applied a single-cell RNA-sequencing approach and assessed the heterogeneity of IL-10-expressing CD4 T cells during chronic infection. more...