GEO DataSets

(Submitter supplied) Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses and cellular differentiation. Soon after expression, e1a binds transiently to cell cycle/growth genes, causing enrichment of p300/CBP, PCAF, H3K18ac, depletion of RB-proteins, and transcriptional activation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL7031 GPL7032

30 Samples

Download data: TSV, TXT

(Submitter supplied) Adenovirus e1a induces quiescent human cells to divide. We found that e1a causes global relocalization of the RB-proteins (RB, p130, p107) and p300/CBP histone acetyltransferases on promoters that restricts H3K18ac to a limited set of genes to stimulate cell cycling and inhibit antiviral responses and cellular differentiation. Soon after expression, e1a binds transiently to cell cycle/growth genes, causing enrichment of p300/CBP, PCAF, H3K18ac, depletion of RB-proteins, and transcriptional activation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL7031 GPL7032

19 Samples

Download data: TSV, TXT

(Submitter supplied) The Whole Human Genome Oligo Microarray Kit is a broad view that represents all known genes and transcripts in the human genome. Sequence was compiled from a broad source survey, and then verified and optimized by alignment to the assembled human genome. Coupled with Agilent's probe selection and robust validation processes, this design delivers increased data quality and less gene coverage redundancy. more...

Organism:

Homo sapiens

6 Series

7 Samples

Download data