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Items: 3

1.

Th1 and T17 activation with and without CB839 treatment

(Submitter supplied) Activated T cells differentiate into functional subsets which require distinct metabolic programs. Glutaminase (GLS) converts glutamine to glutamate to provide substrate for the tricarboxylic acid cycle and epigenetic reactions and here we identify a key role for GLS in T cell activation and specification. Though GLS-deficiency diminished T cell activation, proliferation and impaired differentiation of Th17 cells, loss of GLS also increased Tbet and Interferon-γ expression and CD4 Th1 and CD8 CTL effector cell differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
12 Samples
Download data: TXT
Series
Accession:
GSE112244
ID:
200112244
2.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
3.

Th17 + Vehicle 2

Organism:
Mus musculus
Source name:
Th17 cells
Platform:
GPL21493
Series:
GSE112244
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Sample
Accession:
GSM3061556
ID:
303061556
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db=gds|term=GSM3061556[Accession]|query=1|qty=2|blobid=MCID_66766d5fccfbad768fb0df21|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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