GSM3291581[Accession] - GEO DataSets

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Items: 4

Select item 2001173491.

Divergence in DNA specificity among paralogous transcription factors contributes to their differential in vivo binding [uPBM_E2f1E2f3E2f]

(Submitter supplied) Members of transcription factor (TF) families, i.e. paralogous TFs, are oftentimes reported to have identical DNA-binding motifs, despite the fact that they perform distinct regulatory functions in the cell. Differential genomic targeting by paralogous TFs is generally assumed to be due to interactions with protein cofactors or the chromatin environment. Contrary to previous assumptions, we find that paralogous TFs have different intrinsic preferences for DNA, not captured by current motif models, and these differences partly explain differential genomic binding and functional specificity. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by array

Platform:: GPL23935
3 Samples

Download data: TXT

Series

Accession:: GSE117349

ID:: 200117349

PubMed Full text in PMC Similar studies

Select item 2000977942.

Divergence in DNA specificity among paralogous transcription factors contributes to their differential in vivo binding

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; synthetic construct

Type:: Genome binding/occupancy profiling by array

5 related Platforms
28 Samples

Download data: TXT

Series

Accession:: GSE97794

ID:: 200097794

PubMed Full text in PMC Similar studies

Select item 1000239353.

Universal PBM 4x44k (Bulyk lab design)

(Submitter supplied) In situ oligosynthesized array with synthetic sequences that cover all possible 10-mers (Berger et al., Nature Biotechnology 2006)