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Items: 4

1.

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to PGE2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
34 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE119521
ID:
200119521
2.

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to PGE2 (ATAC-seq)

(Submitter supplied) Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here we show that PGE2 causes mitochondrial membrane potential (Δψm) to dissipate in interleukin-4 activated macrophages (M(IL-4)). Effects on Δψm are a consequence of PGE2-initiated transcriptional regulation of genes in the malate-aspartate shuttle (MAS), particularly GOT1. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
4 Samples
Download data: BIGWIG
Series
Accession:
GSE119463
ID:
200119463
3.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
4.

M2.bigwig

Organism:
Mus musculus
Source name:
bone marrow derived macrophage
Platform:
GPL21493
Series:
GSE119463 GSE119521
Download data: BIGWIG
Sample
Accession:
GSM3375041
ID:
303375041
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Supplemental Content

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