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Items: 3

1.

Shortening the half-life of Cas9 maintains its gene editing ability and reduces neuronal toxicity

(Submitter supplied) Virus-mediated expression of CRISPR/Cas9 has been actively used for genome editing in animal models of genetic disorders, including neurological diseases, but the consequences of overexpressing bacterial Cas9 in the mammalian brain remain unknown. Through RNA-seq analysis, we found that virus-mediated expression of Cas9 caused systematic changes in genes involved in neuronal functions. We also generated a short-lived version of Cas9, which maintains its genome editing capacity, but significantly alleviates neurotoxicity caused by overexpressed Cas9. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
21 Samples
Download data: TXT
Series
Accession:
GSE122072
ID:
200122072
2.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
3.

2_WT-2

Organism:
Mus musculus
Source name:
striatal tissue
Platform:
GPL21493
Series:
GSE122072
Download data
Sample
Accession:
GSM3454286
ID:
303454286
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db=gds|term=GSM3454286[Accession]|query=1|qty=2|blobid=MCID_67ab4020750a117a1d8087f9|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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