GSM3578955[Accession] - GEO DataSets

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Items: 4

Select item 2001256721.

A Mediator-cohesin axis controls heterochromatin domain formation.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL16791 GPL20795
58 Samples

Download data: BED, BROADPEAK, NARROWPEAK, TXT

Series

Accession:: GSE125672

ID:: 200125672

PubMed Full text in PMC Similar studies

Select item 2001256182.

A Mediator-cohesin axis controls heterochromatin domain formation [RNA-seq]

(Submitter supplied) The genome consists of regions of transcriptionally active euchromatin and more silent heterochromatin. We reveal that the formation of heterochromatin domains requires cohesin turnover on DNA. Stabilization of cohesin on DNA through depletion of its release factor WAPL leads to a near-complete loss of heterochromatin domains. The Mediator CDK module controls heterochromatin in an opposing manner. Loss of this module leads to an almost binary partition of the genome into dense H3K9me3 domains, and regions devoid of H3K9me3 spanning the rest of the genome. more...