GSM3617829[Accession] - GEO DataSets

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Items: 4

Select item 2001268981.

A TFAP2C Gene Signature is Predictive of Outcome in HER2 Breast Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL9052
26 Samples

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Series

Accession:: GSE126898

ID:: 200126898

PubMed Full text in PMC Similar studies

Select item 2001268942.

A TFAP2C Gene Signature is Predictive of Outcome in HER2 Breast Cancer (RNA-Seq)

(Submitter supplied) Abstract: A subset of HER2 breast cancers with amplification of the TFAP2C gene locus becomes addicted to AP-2g. We sought to define AP-2g-regulated genes that control growth and invasiveness by comparing HER2 cell lines with differential response to TFAP2C knockdown. A set of 68 differentially expressed genes was identified, which included CDH5 and CDKN1A. Pathway analysis implicated the MAPK13/p38δ and retinoic acid regulatory nodes, which were confirmed to display divergent responses. more...