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Items: 3

1.

EBF1-mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential

(Submitter supplied) Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem and cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Ebf1-deficient MSCs have reduced mesenchymal lineage potential. Ebf1 deletion in Cxcl12-abundant reticular (CAR) cells and PDGFRα+Sca1+CD45-CD31-Lin- (PαS) cells in the bone marrow decreased the numbers of HSPCs and myeloid cells. EBF1 in the bone marrow niche regulates a transcriptional program that determines the functional interactions with HSCs and the long-term balance between the myeloid and lymphoid cell fates.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21493 GPL19057
20 Samples
Download data: BW, TXT
Series
Accession:
GSE127970
ID:
200127970
2.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
3.

PaS cells – Ebf1+/+ Replicate 2

Organism:
Mus musculus
Source name:
Bone marrow CD45-CD31-Lin-PDGFRα+ Sca1+ cells
Platform:
GPL21493
Series:
GSE127970
Download data: BW
Sample
Accession:
GSM3659314
ID:
303659314
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db=gds|term=GSM3659314[Accession]|query=1|qty=2|blobid=MCID_666b6a0d909a3d46ad7c2e4b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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