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Items: 4

1.

RAG-mediated DNA breaks attenuate PU.1 activity in early B cells through activation of a SPIC-BCLAF1 complex

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
26 Samples
Download data: BIGWIG
Series
Accession:
GSE129130
ID:
200129130
2.

RAG-mediated DNA breaks attenuate PU.1 activity in early B cells through activation of a SPIC-BCLAF1 complex [ChIP-Seq]

(Submitter supplied) RAG DSBs trigger ATM-dependent induction of SPIC, an ETS family transcriptional repressor with significant homology to PU.1. RAG DSB-mediated expression of SPIC results in displacement of PU.1 throughout the genome and induction of broad transcriptional changes in pre B cells. SPIC also binds and recruits a unique partner, BCLAF1 to gene regulatory elements that regulate expression of key B cell developmental genes.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
11 Samples
Download data: BIGWIG
Series
Accession:
GSE129124
ID:
200129124
3.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
4.

Input_Art SPIC_tet

Organism:
Mus musculus
Source name:
pre-B cells
Platform:
GPL21493
Series:
GSE129124 GSE129130
Download data
Sample
Accession:
GSM3700783
ID:
303700783
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Supplemental Content

db=gds|term=GSM3700783[Accession]|query=1|qty=2|blobid=MCID_666c68eb909a3d46ad94ad89|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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