GSM4212270[Accession] - GEO DataSets

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Items: 3

Select item 2001417121.

The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks

(Submitter supplied) DNA damage tolerance (DDT) is crucial for genome integrity maintenance. DDT is mainly carried out by template switch recombination, an error-free mode of overcoming DNA lesions, or translesion DNA synthesis, which is error-prone. Here we investigated the role of Mgs1/WRNIP1 in modulating DDT. Using budding yeast, we found that elimination of Mgs1 in cells lacking Rad5, an essential protein for DDT, activates an alternative mode of DNA damage bypass, driven by recombination, that allows chromosome replication and cell viability under stress conditions that block DNA replication forks. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL7250
16 Samples

Download data: BAR, CEL

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Accession:: GSE141712

ID:: 200141712

PubMed Full text in PMC Similar studies

Select item 1000072502.

[Sc03b_MR] Affymetrix GeneChip S. cerevisiae Tiling 1.0R Array

(Submitter supplied) Tiling array submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html BPMAP and other files can be downloaded from the Affymetrix Web site below. Protocol: Designed for identifying novel transcripts, mapping sites of protein/DNA interaction in chromatin immunoprecipitation (ChIP) experiments, and other whole-genome experiments Single array comprised of over 3.2 million perfect match/mismatch probe pairs tiled through the complete Saccharomyces cerevisiae genome. more...